Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with
cell metabolism that represents a novel epigenetic code affecting the fate of cells including …

Abstract Cluster of differentiation 47 (CD47) is a transmembrane protein that is ubiquitously
found on the surface of many cells in the body and uniquely overexpressed by both solid …

Macrophages are essential in eliciting antibody-dependent cellular phagocytosis (ADCP) of
cancer cells. However, a satisfactory anticancer efficacy of ADCP is contingent on early …

Purpose: Phosphatase and tensin homolog (PTEN) loss of function occurs in approximately
50% of patients with metastatic castrate-resistant prostate cancer (mCRPC), and is …

Although immune checkpoint inhibition has been shown to effectively activate antitumor
immunity in various tumor types, only a small subset of patients can benefit from PD-1/PD-L1 …

CTNNB1, encoding the ß-catenin protein, is a key oncogene contributing to liver
carcinogenesis. Hepatocellular carcinoma (HCC) is the most common form of primary liver …

In this study, we explored the oncogenic mechanism of cleavage and polyadenylation-
specific factor 6 (CPSF6) in hepatocellular carcinoma (HCC). CPSF6 was overexpressed in …

Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted
therapy due to the negative expression of the estrogen receptor, progesterone receptor, and …

Immunotherapy has been developing at an unprecedented speed with promising
therapeutic outcomes in the wide spectrum of cancers. Up until now, most immunotherapies …

This review focuses on the evolving understanding that we have of tumor cell metabolism,
particularly glycolytic and oxidative metabolism, and traces back its evolution through time …