The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

Parkinson's disease is a frequent neurodegenerative disease that is mostly known for its
motor symptoms. However, cognitive impairment is now recognised as an important part of …

Escherichia coli was engineered to produce d-pantothenic acid via systematic metabolic
engineering. Firstly, genes of acetohydroxy acid synthase II, pantothenate synthetase, 3 …

Pathogenic bacteria possess a remarkable ability to adapt to fluctuating host environments
and cause infection. Disturbing bacterial central metabolism through inhibition of 1-deoxy-d …

The emergence of X-ray free-electron lasers has led to the development of serial
macromolecular crystallography techniques, making it possible to study smaller and more …

A protein-derived cofactor is a catalytic or redox-active site in a protein that is formed by post-
translational modification of one or more amino acid residues. These post-translational …

Escherichia coli is a ubiquitous group of bacteria that can be either commensal gut microbes
or enterohemorrhagic food-borne pathogens. Regardless, both forms must survive acidic …

The emergence of multidrug resistant bacteria has prioritized the development of new
antibiotics. N-substituted pantothenamides, analogs of the natural compound pantetheine …

Pantothenamides are potent growth inhibitors of the malaria parasite Plasmodium
falciparum. Their clinical use is, however, hindered due to the ubiquitous presence of …

Bacterial l-aspartate α-decarboxylase (PanD) specifically catalyzes the decarboxylation of l-
aspartic acid to β-alanine. It is translated as an inactive pro-protein, then processed by self …