Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …

In our ageing global population, the cognitive decline associated with dementia and
neurodegenerative diseases represents a major healthcare problem. To date, there are no …

Aging is a major risk factor for many diseases. Accurate methods for predicting age in
specific cell types are essential to understand the heterogeneity of aging and to assess …

Partial reprogramming (pulsed expression of reprogramming transcription factors) improves
the function of several tissues in old mice. However, it remains largely unknown how partial …

Yamanaka factors (YFs) can reverse some aging features in mammalian tissues, but their
effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in …

The vasculature is a key component of adult brain neural stem cell (NSC) niches. In the adult
mammalian hippocampus, NSCs reside in close contact with a dense capillary network …

The blood-brain barrier (BBB) serves as a protective interface between the systemic
circulation and the brain parenchyma, limiting the passage of toxins and protein-rich fluid …

Chromatin accessibility profiling is a cornerstone in epigenomic exploration, providing
insights into the regulatory mechanisms that orchestrate gene expression. Understanding …