Targeting neuronal epigenomes for brain rejuvenation
S Zocher - The EMBO Journal, 2024 - embopress.org
Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …
and possible interventions to prevent this cognitive decline have been the focus of intense …
Ageing, cognitive decline, and effects of physical exercise: complexities, and considerations from animal models
In our ageing global population, the cognitive decline associated with dementia and
neurodegenerative diseases represents a major healthcare problem. To date, there are no …
neurodegenerative diseases represents a major healthcare problem. To date, there are no …
[HTML][HTML] CellBiAge: Improved single-cell age classification using data binarization
D Yu, M Li, G Linghu, Y Hu, KH Hajdarovic, A Wang… - Cell reports, 2023 - cell.com
Aging is a major risk factor for many diseases. Accurate methods for predicting age in
specific cell types are essential to understand the heterogeneity of aging and to assess …
specific cell types are essential to understand the heterogeneity of aging and to assess …
Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche
Partial reprogramming (pulsed expression of reprogramming transcription factors) improves
the function of several tissues in old mice. However, it remains largely unknown how partial …
the function of several tissues in old mice. However, it remains largely unknown how partial …
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming
YR Shen, S Zaballa, X Bech, A Sancho-Balsells… - bioRxiv, 2023 - biorxiv.org
Yamanaka factors (YFs) can reverse some aging features in mammalian tissues, but their
effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in …
effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in …
Autocrine VEGF drives neural stem cell proximity to the adult hippocampus vascular niche
TJ Dause, JK Denninger, R Osap… - Life Science …, 2024 - life-science-alliance.org
The vasculature is a key component of adult brain neural stem cell (NSC) niches. In the adult
mammalian hippocampus, NSCs reside in close contact with a dense capillary network …
mammalian hippocampus, NSCs reside in close contact with a dense capillary network …
N-cadherin Adhesion-Mediated Signaling Supports the Blood-Brain Barrier and Cognitive Function
Q Lee - 2024 - search.proquest.com
The blood-brain barrier (BBB) serves as a protective interface between the systemic
circulation and the brain parenchyma, limiting the passage of toxins and protein-rich fluid …
circulation and the brain parenchyma, limiting the passage of toxins and protein-rich fluid …
Advancing the Biological Insights of Chromatin Accessibility Profiling: Improved Methodologies Spanning From Bulk Populations Down to Single-Cell Resolution
H Zhang - 2023 - repository.arizona.edu
Chromatin accessibility profiling is a cornerstone in epigenomic exploration, providing
insights into the regulatory mechanisms that orchestrate gene expression. Understanding …
insights into the regulatory mechanisms that orchestrate gene expression. Understanding …