Rodents are the most widely used species for scientific purposes. A critical pre-requisite of
their use, based on utilitarian ethical reasoning, is the provision of a humane death when …

The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of
psychosis and, most recently, its antidepressant properties. Understanding the physiology of …

Neural synchrony is intricately balanced in the normal resting brain but becomes altered in
Alzheimer's disease (AD). To determine the neurophysiological manifestations associated …

It has been known since the time of patient HM and Karl Lashley's equipotentiality studies
that the hippocampus and cortex serve mnestic functions. Current memory models maintain …

The healthy conscious brain is thought to operate near a critical state, reflecting optimal
information processing and high susceptibility to external stimuli. Conversely, deviations …

Sleep is intimately related to memory processes. The established view is that the
transformation of experiences into long-term memories is linked to sleep-related CNS …

In this paper we propose a new method for the automatic recognition of the state of
behavioral sleep (BS) and waking state (WS) in freely moving rats using their …

The sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM
(NREM) and REM sleep. These states are associated with drastic changes in cognitive …

Background Habituation is defined as a progressive decline in response to repeated
exposure to a familiar and predictable stimulus and is highly conserved across species …

Research has shown that inflammatory processes affect brain function and behavior through
several neuroimmune pathways. However, high order brain functions affected by …