The covalent modification of RNA molecules is a pervasive feature of all classes of RNAs
and has fundamental roles in the regulation of several cellular processes. Mapping the …

In the last decade, the notion that mRNA modifications are involved in regulation of gene
expression was demonstrated in thousands of studies. To date, new technologies and …

Molecular diagnosis of COVID-19 primarily relies on the detection of RNA of the SARS-CoV-
2 virus, the causative infectious agent of the pandemic. Reverse transcription polymerase …

A call for direct sequencing of full-length RNAs to identify all modifications | Nature Genetics
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Direct RNA sequencing for the epitranscriptomic modification pseudouridine (Ψ), an isomer
of uridine (U), was conducted with a protein nanopore sensor using a helicase brake to …

Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

The precise mapping and quantification of the numerous RNA modifications that are present
in tRNAs, rRNAs, ncRNAs/miRNAs, and mRNAs remain a major challenge and a top priority …

Next generation sequencing (NGS) has provided biologists with an unprecedented view into
biological processes and their regulation over the past 2 decades, fueling a wave of …

The biological relevance and dynamics of mRNA modifications have been extensively
studied; however, whether rRNA modifications are dynamically regulated, and under which …

RNA modifications and their corresponding epitranscriptomic writer and eraser enzymes
regulate gene expression. Altered RNA modification levels, dysregulated writers, and …