Brief update on endocytosis of nanomedicines

S Patel, J Kim, M Herrera, A Mukherjee… - Advanced drug delivery …, 2019 - Elsevier
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Salmonella – the ultimate insider. Salmonella virulence factors that modulate intracellular survival

JA Ibarra, O Steele‐Mortimer - Cellular microbiology, 2009 - Wiley Online Library
Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen
that causes food‐borne gastroenteritis in millions of people worldwide. Intracellular survival …

Inflammatory caspases are innate immune receptors for intracellular LPS

J Shi, Y Zhao, Y Wang, W Gao, J Ding, P Li, L Hu… - Nature, 2014 - nature.com
The murine caspase-11 non-canonical inflammasome responds to various bacterial
infections. Caspase-11 activation-induced pyroptosis, in response to cytoplasmic …

Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole

CL Birmingham, AC Smith, MA Bakowski… - Journal of Biological …, 2006 - ASBMB
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular
pathogen that causes disease in a variety of hosts. S. Typhimurium actively invade host cells …

Life on the inside: the intracellular lifestyle of cytosolic bacteria

K Ray, B Marteyn, PJ Sansonetti… - Nature Reviews …, 2009 - nature.com
Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

Galectin‐3, a marker for vacuole lysis by invasive pathogens

I Paz, M Sachse, N Dupont, J Mounier… - Cellular …, 2010 - Wiley Online Library
Shigella bacteria invade macrophages and epithelial cells and following internalization lyse
the phagosome and escape to the cytoplasm. Galectin‐3, an abundant protein in …

The autophagy receptor TAX1BP1 and the molecular motor myosin VI are required for clearance of salmonella typhimurium by autophagy

DA Tumbarello, PT Manna, M Allen, M Bycroft… - PLoS …, 2015 - journals.plos.org
Autophagy plays a key role during Salmonella infection, by eliminating these pathogens
following escape into the cytosol. In this process, selective autophagy receptors, including …

Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections

NF Kamaruzzaman, S Kendall… - British journal of …, 2017 - Wiley Online Library
Infectious diseases continue to threaten human and animal health and welfare globally,
impacting millions of lives and causing substantial economic loss. The use of antibacterials …

LPS Remodeling Triggers Formation of Outer Membrane Vesicles in Salmonella

W Elhenawy, M Bording-Jorgensen, E Valguarnera… - MBio, 2016 - Am Soc Microbiol
Outer membrane vesicles (OMV) are proposed to mediate multiple functions during
pathogenesis and symbiosis. However, the mechanisms responsible for OMV formation …

Recognition of bacteria in the cytosol of mammalian cells by the ubiquitin system

AJ Perrin, X Jiang, CL Birmingham, NSY So… - Current biology, 2004 - cell.com
Recent studies have suggested the existence of innate host surveillance systems for the
detection of bacteria in the cytosol of mammalian cells [1–4]. The molecular details of how …