Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Nanomaterials for T-cell cancer immunotherapy

N Gong, NC Sheppard, MM Billingsley, CH June… - Nature …, 2021 - nature.com
T-cell-based immunotherapies hold promise for the treatment of many types of cancer, with
three approved products for B-cell malignancies and a large pipeline of treatments in clinical …

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

B Farhood, M Najafi… - Journal of cellular …, 2019 - Wiley Online Library
CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer.
During cancer progression, CTLs encounter dysfunction and exhaustion due to …

Hybrid nanomaterials for cancer immunotherapy

J Li, W Lu, Y Yang, R Xiang, Y Ling, C Yu… - Advanced …, 2023 - Wiley Online Library
Nano‐immunotherapy has been recognized as a highly promising strategy for cancer
treatment in recent decades, which combines nanotechnology and immunotherapy to …

Macrophage polarity in cancer: a review

M Najafi, N Hashemi Goradel… - Journal of cellular …, 2019 - Wiley Online Library
Macrophages are the most abundant cells within the tumor stroma displaying noticeable
plasticity, which allows them to perform several functions within the tumor microenvironment …

Immunomodulatory nanosystems

X Feng, W Xu, Z Li, W Song, J Ding… - Advanced science, 2019 - Wiley Online Library
Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Signal transducer and activator of transcription (STATs) proteins in cancer and inflammation: functions and therapeutic implication

CY Loh, A Arya, AF Naema, WF Wong, G Sethi… - Frontiers in …, 2019 - frontiersin.org
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Q Lu, D Kou, S Lou, M Ashrafizadeh, AR Aref… - Journal of Hematology & …, 2024 - Springer
Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Thirty years of cancer nanomedicine: success, frustration, and hope

L Salvioni, MA Rizzuto, JA Bertolini, L Pandolfi… - Cancers, 2019 - mdpi.com
Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine
has gained a crucial role in cancer treatment. The advances in the field have led to the …

Contribution of regulatory T cells to cancer: A review

M Najafi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
Regulatory T cells (Tregs) represent a low number of T‐cell population under normal
conditions, and they play key roles for maintaining immune system in homeostasis. The …