Chlorogenic acids (CGAs), a group of hydroxycinnamates, are generally abundant in
everyday foods and beverages, most prominently in certain coffee drinks. Among them, the …

Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

Diabetic nephropathy (DN) is known as a major microvascular complication in type 1
diabetes. The effect of insulin treatment alone on controlling blood glucose is unsatisfactory …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …

Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …

Exposure to chronic adverse conditions, and the resultant activation of the neurobiological
response cascade, has been associated with an increased risk of early onset of age-related …

The link between chronic psychosocial and metabolic stress and the pathogenesis of
disease has been extensively documented. Nevertheless, the cellular mechanisms by which …

The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …