Role of RUNX1 in hematological malignancies
R Sood, Y Kamikubo, P Liu - … Journal of the American Society of …, 2017 - ashpublications.org
RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
H Döhner, EH Estey, S Amadori… - Blood, The Journal …, 2010 - ashpublications.org
In 2003, an international working group last reported on recommendations for diagnosis,
response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that …
response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that …
Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia
T Herold, M Rothenberg-Thurley, VV Grunwald… - Leukemia, 2020 - nature.com
Abstract The revised 2017 European LeukemiaNet (ELN) recommendations for genetic risk
stratification of acute myeloid leukemia have been widely adopted, but have not yet been …
stratification of acute myeloid leukemia have been widely adopted, but have not yet been …
Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia
Patients with acute myeloid leukemia (AML) harboring FLT3 internal tandem duplications
(ITDs) have poor outcomes, in particular AML with a high (≥ 0.5) mutant/wild-type allelic …
(ITDs) have poor outcomes, in particular AML with a high (≥ 0.5) mutant/wild-type allelic …
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 …
D Grimwade, RK Hills, AV Moorman… - Blood, The Journal …, 2010 - ashpublications.org
Diagnostic karyotype provides the framework for risk-stratification schemes in acute myeloid
leukemia (AML); however, the prognostic significance of many rare recurring cytogenetic …
leukemia (AML); however, the prognostic significance of many rare recurring cytogenetic …
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
RF Schlenk, K Döhner, J Krauter… - … England Journal of …, 2008 - Mass Medical Soc
Background Mutations occur in several genes in cytogenetically normal acute myeloid
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 …
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 …
Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia
Purpose To evaluate the prognostic significance of the international European LeukemiaNet
(ELN) guidelines for reporting genetic alterations in acute myeloid leukemia (AML). Patients …
(ELN) guidelines for reporting genetic alterations in acute myeloid leukemia (AML). Patients …
Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom …
JAL Yin, MA O'Brien, RK Hills, SB Daly… - Blood, The Journal …, 2012 - ashpublications.org
The clinical value of serial minimal residual disease (MRD) monitoring in core binding factor
(CBF) acute myeloid leukemia (AML) by quantitative RT-PCR was prospectively assessed in …
(CBF) acute myeloid leukemia (AML) by quantitative RT-PCR was prospectively assessed in …
Acute myeloid leukaemia
E Estey, H Döhner - The Lancet, 2006 - thelancet.com
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic
progenitor cells and the most common malignant myeloid disorder in adults. The median …
progenitor cells and the most common malignant myeloid disorder in adults. The median …
Comprehensive mutational profiling of core binding factor acute myeloid leukemia
N Duployez, A Marceau-Renaut… - Blood, The Journal …, 2016 - ashpublications.org
Acute myeloid leukemia (AML) with t (8; 21) or inv (16) have been recognized as unique
entities within AML and are usually reported together as core binding factor AML (CBF …
entities within AML and are usually reported together as core binding factor AML (CBF …