Targeted mechanical stimulation via magnetic nanoparticles guides in vitro tissue development

AR Abdel Fattah, N Kolaitis, K Van Daele… - Nature …, 2023 - nature.com
Tissues take shape through a series of morphogenetic movements guided by local cell-
scale mechanical forces. Current in vitro approaches to recapitulate tissue mechanics rely …

Engineering the physical microenvironment into neural organoids for neurogenesis and neurodevelopment

M Li, H Sun, Z Hou, S Hao, L Jin, B Wang - Small, 2024 - Wiley Online Library
Understanding the signals from the physical microenvironment is critical for deciphering the
processes of neurogenesis and neurodevelopment. The discovery of how surrounding …

A controllable perfusion microfluidic chip for facilitating the development of retinal ganglion cells in human retinal organoids

J Gong, Y Gong, T Zou, Y Zeng, C Yang, L Mo, J Kang… - Lab on a Chip, 2023 - pubs.rsc.org
Retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) have become a
promising model in vitro to recapitulate human retinal development, which can be further …

Minireview: Insights into the role of TRP channels in the retinal circulation and function

S Thébault - Neuroscience letters, 2021 - Elsevier
Consistent with their wide distribution throughout the CNS, transcripts of all transient
receptor potential (TRP) cation channel superfamily members have been detected in both …

Graphene-based microfluidic perforated microelectrode arrays for retinal electrophysiological studies

A Esteban-Linares, X Zhang, HH Lee, ML Risner… - Lab on a Chip, 2023 - pubs.rsc.org
Perforated microelectrode arrays (pMEAs) have become essential tools for ex vivo retinal
electrophysiological studies. pMEAs increase the nutrient supply to the explant and alleviate …

Incubator-independent perfusion system integrated with microfluidic device for continuous electrophysiology and microscopy readouts

R Habibey - Biofabrication, 2023 - iopscience.iop.org
Advances in primary and stem cell derived neuronal cell culture techniques and abundance
of available neuronal cell types have enabled in vitro neuroscience as a substantial …

Machine Learning Approaches to 3D Models for Drug Screening

VA da Silva, R Sharma, E Shteinberg, V Patel… - Biomedical Materials & …, 2024 - Springer
The creation of precise, functional 3D tissues can enable effective drug screening as well as
advancements in regenerative medicine. However, the inherent limitations present during …

[HTML][HTML] The response of retinal ganglion cells to optical defocused visual stimuli in mouse retinas

C So, T Zhang, Q Wang, C Qiu, DLA Elie… - Experimental Eye …, 2024 - Elsevier
Myopia and astigmatism are two primary types of refractive errors characterized by
inaccurate focusing images on the retina. This study aimed to investigate the response …

Local actuation of organoids by magnetic nanoparticles

AR Abdel Fattah, N Kolaitis, K Van Daele, AG Rustandi… - BioRxiv, 2022 - biorxiv.org
Tissues take shape during development through a series of morphogenetic movements
guided by local cell-scale forces. While current in vitro approaches subjecting tissues to …

[HTML][HTML] Single cell electrophysiological alterations under dynamic loading at ultrasonic frequencies

M Tamayo-Elizalde, C Kayal, H Ye, A Jérusalem - Brain Multiphysics, 2021 - Elsevier
The use of ultrasound as a non-invasive means to modulate neuronal electrophysiological
signals in experimental in vivo and in vitro models has recently been gaining momentum …