Breast cancer is the second leading cause of cancer deaths among women. The
development of breast cancer is a multi-step process involving multiple cell types, and its …

Cardiovascular disease (CVD) remains the leading cause of mortality in women, yet many
people perceive breast cancer to be the number one threat to women's health. CVD and …

Breast cancer is treated with a multidisciplinary approach involving surgical oncology,
radiation oncology, and medical oncology. The NCCN Clinical Practice Guidelines in …

PURPOSE Many patients with HR+, HER2− early breast cancer (EBC) will not experience
recurrence or have distant recurrence with currently available standard therapies. However …

Seventy percent of breast cancers express estrogen receptor (ER), and most of these are
sensitive to ER inhibition. However, many such tumors for unknown reasons become …

Background Adjuvant endocrine therapy compromises bone health in patients with breast
cancer, causing osteopenia, osteoporosis, and fractures. Antiresorptive treatments such as …

Long-term survival rates after a diagnosis of breast cancer are steadily rising. This is good
news, but clinicians must also recognize that this brings new challenges to the medical …

Background In postmenopausal women with hormone receptor-positive, early-stage breast
cancer, treatment with adjuvant aromatase inhibitors is the standard of care, but it increases …

Both solid tumours and leukaemias show considerable histological and functional
heterogeneity. It is widely accepted that genetic lesions have a major role in determining …

The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …