During the last two decades, tetrabutylammonium bromide (TBAB) has gained significant
attention as an efficient metal-free homogeneous phase-transfer catalyst. A catalytic amount …

ABSTRACT The reaction of 2, 6-dimethyl-4-phenyl-1, 4-dihydropyridine-3, 5-
dicarbohydrazide with variety of carbonyl compounds such as substituted benzaldehydes …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Materials and Methods: The human breast cancer cell line T47D was used for this
experiment. T47D CSCs were isolated by magnetic bead sorting using the MACS system …

Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal
chemistry. Among all of the heterocyclic scaffolds, 1, 4-Dihydropyridine (1, 4-DHP) is one of …

The aim of this study was to investigate the in vitro cytotoxic activity of total extract of MeOH
(70%) and partition fractions of hexan, chloroform (CHCL3), ethylacetate (EtOAc) and MeOH …

Drug resistance limits the success of many anticancer drugs. Reduced accumulation of the
drug at its intracellular site of action because of overexpression of efflux transporters such as …

Introduction: In the past, clinical studies had demonstrated that aspirin and NSAIDs reduce
the risk of colorectal cancer. After the discovery of selective prostaglandin-endoperoxide …

Plants as important source of natural active components with anticancer effects commonly
are different in structure and biological properties. The pericarp of Pistacia atlantica sub …

Abstract Many 1, 4-dihydropyridines hybrid with 1, 2, 4-triazole 4a-l were synthesized by the
reaction of 5, 5′-(2, 6-dimethyl-4-phenyl-1, 4-dihydropyridine-3, 5-diyl) bis (4-amino-4H-1 …