Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

The respiratory system, which consists of the lungs, trachea and associated vasculature, is
essential for terrestrial life. In recent years, extensive progress has been made in defining …

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …

Lung branching morphogenesis is a highly orchestrated process that gives rise to the
complex network of gas-exchanging units in the adult lung. Intricate regulation of signaling …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

The family of Rho GTPases are intracellular signal transducers that link cell surface signals
to multiple intracellular responses. They are best known for their role in regulating actin …

Epithelial cells undergo dynamic polarity changes as organs pattern, but the relationship
between epithelial polarity and cell fate is poorly understood. Using the developing lung as …

Epithelial permeability is a hallmark of mucosal inflammation, but the molecular mechanisms
involved remain poorly understood. A key component of the epithelial barrier is the apical …