The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …

Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that
consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a …

Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG)
development, is determined by the immense structural diversity of sulfated HS domains. 3-O …

HS3ST1 is a genetic risk gene associated with Alzheimer's disease (AD) and overexpressed
in patients, but how it contributes to the disease progression is unknown. We report the …

Leucocyte recruitment is a critical component of the immune response and is central to our
ability to fight infection. Paradoxically, leucocyte recruitment is also a central component of …

Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream
infections and catheter-related thrombosis, are life-threatening complications. Herein, we …

Chemokine-driven leukocyte recruitment is a key component of the immune response and of
various diseases. Therapeutically targeting the chemokine system in inflammatory disease …

Abstract Engrailed2 (En2) is a transcription factor that transfers from cell to cell through
unconventional pathways. The poorly understood internalization mechanism of this cationic …