COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

A Parasher - Postgraduate medical journal, 2021 - academic.oup.com
Background The severe acute respiratory syndrome (SARS) coronavirus-2 is a novel
coronavirus belonging to the family Coronaviridae and is now known to be responsible for …

[HTML][HTML] Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis

X Fang, S Li, H Yu, P Wang, Y Zhang, Z Chen… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
A systematic review and meta-analysis was conducted in an attempt to systematically collect
and evaluate the associations of epidemiological, comorbidity factors with the severity and …

[HTML][HTML] Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts

J Hellewell, S Abbott, A Gimma, NI Bosse… - The Lancet Global …, 2020 - thelancet.com
Background Isolation of cases and contact tracing is used to control outbreaks of infectious
diseases, and has been used for coronavirus disease 2019 (COVID-19). Whether this …

[HTML][HTML] Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020

JA Backer, D Klinkenberg, J Wallinga - Eurosurveillance, 2020 - eurosurveillance.org
A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in
Wuhan, China. Using the travel history and symptom onset of 88 confirmed cases that were …

[HTML][HTML] Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

S Wang, T Dai, Z Qin, T Pan, F Chu, L Lou, L Zhang… - Nature Cell …, 2021 - nature.com
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …

Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms

E Ahmadian, SM Hosseiniyan Khatibi… - Reviews in medical …, 2021 - Wiley Online Library
The novel coronavirus (SARS‐CoV‐2) has turned into a life‐threatening pandemic disease
(Covid‐19). About 5% of patients with Covid‐19 have severe symptoms including septic …

Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study

H Qiu, J Wu, L Hong, Y Luo, Q Song… - The Lancet infectious …, 2020 - thelancet.com
Summary Background Since December, 2019, an outbreak of coronavirus disease 2019
(COVID-19) has spread globally. Little is known about the epidemiological and clinical …

Severe acute respiratory syndrome: historical, epidemiologic, and clinical features

DSC Hui, A Zumla - Infectious Disease Clinics, 2019 - id.theclinics.com
Over the past 2 decades 2 previously unknown coronaviruses (CoVs), the severe acute
respiratory syndrome CoV (SARS-CoV) and the Middle East respiratory syndrome CoV …

[HTML][HTML] Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China

JT Wu, K Leung, M Bushman, N Kishore, R Niehus… - Nature medicine, 2020 - nature.com
As of 29 February 2020 there were 79,394 confirmed cases and 2,838 deaths from COVID-
19 in mainland China. Of these, 48,557 cases and 2,169 deaths occurred in the epicenter …

[HTML][HTML] Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: a statistical analysis of publicly available …

NM Linton, T Kobayashi, Y Yang, K Hayashi… - Journal of clinical …, 2020 - mdpi.com
The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter
of Wuhan, China, has provided an opportunity to study the natural history of the recently …