Effects of local anesthetics on articular cartilage

SL Piper, JD Kramer, HT Kim… - The American journal of …, 2011 - journals.sagepub.com
Background: Recent basic science studies have demonstrated local anesthetic
chondrotoxicity in vivo and in vitro in both human and animal cartilage. Clinically …

Published evidence demonstrating the causation of glenohumeral chondrolysis by postoperative infusion of local anesthetic via a pain pump

FA Matsen III, A Papadonikolakis - JBJS, 2013 - journals.lww.com
Background: Glenohumeral chondrolysis is the irreversible destruction of previously normal
articular cartilage, occurring most commonly after shoulder surgery in young individuals. The …

The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage

A Breu, K Rosenmeier, R Kujat, P Angele… - Anesthesia & …, 2013 - journals.lww.com
BACKGROUND: Intraarticular injections of local anesthetics are frequently used as part of
multimodal pain regimens. However, recent data suggest that local anesthetics affect …

Cytotoxicity of local anesthetics on human mesenchymal stem cells in vitro

A Breu, S Eckl, W Zink, R Kujat, P Angele - Arthroscopy: The Journal of …, 2013 - Elsevier
Purpose The purpose of this study was to investigate the cytotoxic potency of local
anesthetics on human mesenchymal stem cells (MSCs) before and after chondrogenic …

Articular cartilage and local anaesthetic: a systematic review of the current literature

A Gulihar, S Robati, H Twaij, A Salih, GJS Taylor - Journal of orthopaedics, 2015 - Elsevier
Background Chondrolysis involves the breakdown of cartilage following arthroscopic
surgery, most commonly affecting the glenohumeral joint. Methods This review summarises …

Chondrolysis of the glenohumeral joint after infusion of bupivacaine through an intra-articular pain pump catheter: a report of 18 cases

SL Anderson, JZ Buchko, MR Taillon… - Arthroscopy: The Journal of …, 2010 - Elsevier
PURPOSE: To report on our experience of patients who received infusion of bupivacaine
with epinephrine after arthroscopic glenoid labral repair surgery and in whom glenohumeral …

The development of postoperative knee chondrolysis after intra-articular pain pump infusion of an anesthetic medication: a series of twenty-one cases

FR Noyes, CM Fleckenstein, SD Barber-Westin - JBJS, 2012 - journals.lww.com
Background: Postoperative chondrolysis in the knee joint caused by continuous intra-
articular pain pumps infusing bupivacaine is a serious complication that severely affects …

Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system

D Wang, NV Vo, GA Sowa, RA Hartman, K Ngo… - The Spine Journal, 2011 - Elsevier
BACKGROUND CONTEXT: Bupivacaine is a local anesthetic commonly used for back pain
management in interventional procedures. Cytotoxic effects of bupivacaine have been …

Knee chondrolysis by infusion of bupivacaine with epinephrine through an intra-articular pain pump catheter after arthroscopic ACL reconstruction

JZ Buchko, T Gurney-Dunlop… - The American Journal of …, 2015 - journals.sagepub.com
Background: Postoperative knee chondrolysis caused by continuous intra-articular pain
pumps infusing bupivacaine with epinephrine is a rare but serious complication. Purpose …

Perioperative pain management strategies for anterior cruciate ligament reconstruction

H Jansson, SJ Narvy, N Mehran - JBJS reviews, 2018 - journals.lww.com
Perioperative Pain Management Strategies for Anterior Crucia... : JBJS Reviews
Perioperative Pain Management Strategies for Anterior Cruciate Ligament Reconstruction …