Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von
Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and …

Background The Proteus syndrome is characterized by the overgrowth of skin, connective
tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by …

Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

Mammalian target of rapamycin (mTOR) is a protein kinase involved in translation control
and long-lasting synaptic plasticity. mTOR functions as the central component of two multi …

Because of their ability to become rapidly activated at places of vascular injury, platelets are
important players in primary hemostasis as well as in arterial thrombosis. In addition, they …

Knowledge of the identity and quantity of expressed proteins of a cell type is a prerequisite
for a complete understanding of its molecular functions. Mass-spectrometry-based …

Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …