Polyglutamine diseases are a collection of nine CAG trinucleotide expansion disorders,
presenting with a spectrum of neurological and clinical phenotypes. Recent human, mouse …

The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative
diseases that share convergent disease features. A common symptom of these diseases is …

Toxic proteinaceous deposits and alterations in excitability and activity levels characterize
vulnerable neuronal populations in neurodegenerative diseases. Using in vivo two-photon …

Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features
are at the core of the modular organization of the cerebellum. Previously, we showed that …

In degenerative neurological disorders such as Parkinson's disease, a convergence of
widely varying insults results in a loss of dopaminergic neurons and, thus, the motor …

Background A combination of central muscle relaxants, chlorzoxazone and baclofen
(chlorzoxazone‐baclofen), has been proposed for treatment of cerebellar symptoms in …

Spinocerebellar ataxias are neurodegenerative diseases, the hallmark symptom of which is
the development of ataxia due to cerebellar dysfunction. Purkinje cells, the principal neurons …

Purkinje cells are the primary processing units of the cerebellar cortex and display molecular
heterogeneity that aligns with differences in physiological properties, projection patterns …

Proximal spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative
disorder characterized by motor neuron loss and subsequent atrophy of skeletal muscle …

Spinocerebellar Ataxia Type 6 (SCA6) is a mid-life onset neurodegenerative disease
characterized by progressive ataxia, dysarthria, and eye movement impairment. This …