Background Current estimates suggest that even in the most resourced settings, the
aetiology of encephalitis is identified in less than half of clinical cases. It is acknowledged …

While single-stranded DNA (ssDNA) was once thought to be a relatively rare genomic
architecture for viruses, modern metagenomics sequencing has revealed circular ssDNA …

Torquetenovirus (TTV) is the most abundant component of human virome. Virologists have
long ignored this orphan and highly divergent virus, in part because TTV cannot be cultured …

The application of next-generation sequencing (NGS) techniques for the identification of
viruses present in urban sewage has not been fully explored. This is partially due to a lack of …

The ability to provide a fast, inexpensive and reliable diagnostic for any given viral infection
is a key parameter in efforts to fight and control these ubiquitous pathogens. The recent …

Objective: To determine the feasibility of next-generation sequencing (NGS) microbiome
approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in …

We describe the metagenomics-derived feline enteric virome in the faeces of 25 cats from a
single shelter in California. More than 90% of the recognizable viral reads were related to …

Population (Sanger) sequencing has been the standard method in basic and clinical DNA
sequencing for almost 40 years; however, next-generation (deep) sequencing …

Metagenomics was used to characterize viral genomes in clinical specimens of horses with
various organ-specific diseases of unknown aetiology. A novel parvovirus as well as a …

Viruses with small circular ssDNA genomes encoding a replication initiator protein can infect
a wide range of eukaryotic organisms ranging from mammals to fungi. The genomes of two …