Break-induced replication and genome stability
Genetic instabilities, including mutations and chromosomal rearrangements, lead to cancer
and other diseases in humans and play an important role in evolution. A frequent cause of …
and other diseases in humans and play an important role in evolution. A frequent cause of …
Chromosome position determines the success of double-strand break repair
Repair of a chromosomal double-strand break (DSB) by gene conversion depends on the
ability of the broken ends to encounter a donor sequence. To understand how chromosomal …
ability of the broken ends to encounter a donor sequence. To understand how chromosomal …
Breaks in the 45S rDNA lead to recombination-mediated loss of repeats
DO Warmerdam, J van den Berg, RH Medema - Cell reports, 2016 - cell.com
Summary rDNA repeats constitute the most heavily transcribed region in the human
genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that …
genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that …
Gene Copy-Number Variation in Haploid and Diploid Strains of the Yeast Saccharomyces cerevisiae
H Zhang, AFB Zeidler, W Song, CM Puccia, E Malc… - Genetics, 2013 - academic.oup.com
The increasing ability to sequence and compare multiple individual genomes within a
species has highlighted the fact that copy-number variation (CNV) is a substantial and …
species has highlighted the fact that copy-number variation (CNV) is a substantial and …
Single-strand annealing between inverted DNA repeats: Pathway choice, participating proteins, and genome destabilizing consequences
S Ramakrishnan, Z Kockler, R Evans… - PLoS …, 2018 - journals.plos.org
Double strand DNA breaks (DSBs) are dangerous events that can result from various
causes including environmental assaults or the collapse of DNA replication. While the …
causes including environmental assaults or the collapse of DNA replication. While the …
[HTML][HTML] Functional features of EVI1 and EVI1Δ324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity
The MDS1 and ecotropic viral integration site 1 (EVI1) complex locus (MECOM) gene
encodes several transcription factor variants including MDS1-EVI1, EVI1 and EVI1Δ324 …
encodes several transcription factor variants including MDS1-EVI1, EVI1 and EVI1Δ324 …
Comparative Sequence Analysis of the Ghd7 Orthologous Regions Revealed Movement of Ghd7 in the Grass Genomes
Ghd7 is an important rice gene that has a major effect on several agronomic traits, including
yield. To reveal the origin of Ghd7 and sequence evolution of this locus, we performed a …
yield. To reveal the origin of Ghd7 and sequence evolution of this locus, we performed a …
Interstitial telomeric repeats-associated DNA breaks
O Shubernetskaya, D Skvortsov, S Evfratov… - Nucleus, 2017 - Taylor & Francis
During a cell's lifespan, DNA break formation is a common event, associated with many
processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some …
processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some …
Roles of exonucleases and translesion synthesis DNA polymerases during mitotic gap repair in yeast
X Guo, S Jinks-Robertson - DNA repair, 2013 - Elsevier
Transformation-based gap-repair assays have long been used to model the repair of mitotic
double-strand breaks (DSBs) by homologous recombination in yeast. In the current study …
double-strand breaks (DSBs) by homologous recombination in yeast. In the current study …