Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Abstract Background Long noncoding RNAs (lncRNAs) have emerged as critical players in
cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been …

Thousands of genes have been well demonstrated to play important roles in cancer
progression. As genes do not function in isolation, they can be grouped into “networks” …

It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer
metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a …

Background Research has indicated that the emergence of Schwann cells around
premalignant lesions of colon cancer might be an early indicator promoting the onset of …

Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Objective Claudin-1 expression is increased and dysregulated in colorectal cancer and
causally associates with the dedifferentiation of colonic epithelial cells, cancer progression …

Keratins 8 and 18 (K8/18) are simple epithelial cell-specific intermediate filament proteins.
Keratins are essential for tissue integrity and are involved in intracellular signaling pathways …