Modulation of cellular function by the urokinase receptor signalling: A mechanistic view

D Alfano, P Franco, MP Stoppelli - Frontiers in Cell and …, 2022 - frontiersin.org
Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …

COVID-19 convalescent plasma is more than neutralizing antibodies: a narrative review of potential beneficial and detrimental co-factors

D Focosi, M Franchini, L Pirofski, T Burnouf… - Viruses, 2021 - mdpi.com
COVID-19 convalescent plasma (CCP) is currently under investigation for both treatment
and post-exposure prophylaxis. The active component of CCP mediating improved outcome …

Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants

TG Paranga, M Pavel-Tanasa… - Frontiers in …, 2023 - frontiersin.org
C-reactive protein (CRP) has been one of the most investigated inflammatory-biomarkers
during the ongoing COVID-19 pandemics caused by severe acute respiratory syndrome …

Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methods

S Yu, X Li, Z Xin, L Sun, J Shi - Frontiers in Immunology, 2022 - frontiersin.org
At the end of 2019, the COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2) infection, seriously damaged world public health security …

Association of gut microbial dysbiosis with disease severity, response to therapy and disease outcomes in Indian patients with COVID-19

D Talukdar, P Bandopadhyay, Y Ray, SR Paul, J Sarif… - Gut Pathogens, 2023 - Springer
Background Severe coronavirus disease 2019 (COVID-19) is associated with systemic
hyper-inflammation. An adaptive interaction between gut microbiota and host immune …

Novel inflammatory biomarkers in the prognosis of COVID-19

K Zhan, L Wang, H Lin, X Fang… - … in Respiratory Disease, 2023 - journals.sagepub.com
Background: The central role of inflammatory progression in the development of
Coronavirus disease 2019 (COVID-19), especially in severe cases, is indisputable …

Circulating interleukin-8 dynamics parallels disease course and is linked to clinical outcomes in severe COVID-19

R D'Rozario, D Raychaudhuri, P Bandopadhyay… - Viruses, 2023 - mdpi.com
Severe COVID-19 frequently features a systemic deluge of cytokines. Circulating cytokines
that can stratify risks are useful for more effective triage and management. Here, we ran a …

Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses

B Alghanem, FA Mansour, H Shaibah, K Almuhalhil… - Heliyon, 2023 - cell.com
Abstract Treatment of severe cases of coronavirus disease 2019 (COVID-19) is extremely
important to minimize death and end-organ damage. Here we performed a proteomic …

Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study

P Mehta, P Chattopadhyay, R Mohite… - Life Science …, 2024 - life-science-alliance.org
Understanding the dynamic changes in gene expression during Acute Respiratory Distress
Syndrome (ARDS) progression in post-acute infection patients is crucial for unraveling the …

Targeted imaging of uPAR expression in vivo with cyclic AE105 variants

JM Leth, EA Newcombe, AL Grønnemose… - Scientific Reports, 2023 - nature.com
A comprehensive literature reports on the correlation between elevated levels of urokinase-
type plasminogen activator receptor (uPAR) and the severity of diseases with chronic …