[HTML][HTML] Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

[HTML][HTML] Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

[HTML][HTML] Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

[HTML][HTML] Neutrophils in liver diseases: pathogenesis and therapeutic targets

K Liu, FS Wang, R Xu - Cellular & molecular immunology, 2021 - nature.com
Previously, it was assumed that peripheral neutrophils are a homogeneous population that
displays antimicrobial functions. However, recent data have revealed that neutrophils are …

[HTML][HTML] Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis

Y He, RM Rodrigues, X Wang, W Seo… - The Journal of …, 2021 - Am Soc Clin Investig
Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic
steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure …

[HTML][HTML] Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

J Ma, A Guillot, Z Yang, B Mackowiak… - The Journal of …, 2022 - Am Soc Clin Investig
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

Immune–metabolic interactions in homeostasis and the progression to NASH

JA Hoogerland, B Staels, D Dombrowicz - Trends in Endocrinology & …, 2022 - cell.com
The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …

Immunopathobiology and therapeutic targets related to cytokines in liver diseases

Y He, S Hwang, YA Ahmed, D Feng, N Li… - Cellular & molecular …, 2021 - nature.com
Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

[HTML][HTML] Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2

B Liu, L Xiang, J Ji, W Liu, Y Chen… - The Journal of …, 2021 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of chronic liver disease
ranging from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH). However, the …