Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are …

Abstract: 1, 2, 4-Triazine nucleus is a prominent structural core system present in numerous
pharmacologically active compounds. Till date, various 1, 2, 4-triazine analogs, possesing a …

On account of the reported anticancer of pyrimidine and condensed pyrimidine, a new
pyrimido [3, 2-b]-1, 2, 4, 5-tetrazine 3a, b, 5c, d, 6, 9, pyrimido [3, 2-b]-1, 2, 4-triazine 10, 11 …

Triazines and their oxo derivatives are a representative class of heterocyclic compounds
which have attracted great attention in organic synthesis and medicinal chemistry as they …

Protein misfolding and inclusion body formations are common events in neurodegenerative
diseases characterized by deposition of misfolded proteins inside or outside of neurons, and …

Parkinson's disease (PD) is a neurodegenerative disease featured by selective loss of
substantia nigra neurons. Rotenone administration in animals induces neurodegeneration …

The present study deals with the efficient chemo-enzymatic synthesis of enantiopure (R)-1-
chloro-3-(piperidin-1-yl) propan-2-ol 3, as an intermediate for (R)-arimoclomol. This …

In search for new biologically active compounds, several new fluorine‐substituted pyrimido
[2, 3‐c][1, 2, 4] triazino (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16) have been synthesized …

Glibenclamide (5-chloro-N-(4-[N-(cyclohexylcarbamoyl) sulfamoyl] phenethyl)-2-
methoxybenzamide, Glyburide, E) is a well-known and potent second-generation of …

New thienopyrimidine derivatives substituted with amino and hydrazinyl side chains were
synthesized starting with 2-hydrazinyl substituted thienopyrimidine as a key compound. The …