Mechanics and functional consequences of nuclear deformations
As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …
fate and function in response to various signals and stimuli. In addition to biochemical …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
Nuclear envelope rupture and repair during cancer cell migration
During cancer metastasis, tumor cells penetrate tissues through tight interstitial spaces,
which requires extensive deformation of the cell and its nucleus. Here, we investigated …
which requires extensive deformation of the cell and its nucleus. Here, we investigated …
[HTML][HTML] Mechanical regulation of transcription: recent advances
Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
Cell migration has two opposite faces: although necessary for physiological processes such
as immune responses, it can also have detrimental effects by enabling metastatic cells to …
as immune responses, it can also have detrimental effects by enabling metastatic cells to …
Actin on and around the Nucleus
PM Davidson, B Cadot - Trends in Cell Biology, 2021 - cell.com
Actin plays roles in many important cellular processes, including cell motility, organelle
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …
movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the …
Generation of stress fibers through myosin-driven reorganization of the actin cortex
JI Lehtimäki, EK Rajakylä, S Tojkander, P Lappalainen - Elife, 2021 - elifesciences.org
Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
Nesprin-2G, a component of the nuclear LINC complex, is subject to myosin-dependent tension
PT Arsenovic, I Ramachandran, K Bathula, R Zhu… - Biophysical journal, 2016 - cell.com
The nucleus of a cell has long been considered to be subject to mechanical force. Despite
the observation that mechanical forces affect nuclear geometry and movement, how forces …
the observation that mechanical forces affect nuclear geometry and movement, how forces …
Squish and squeeze—the nucleus as a physical barrier during migration in confined environments
From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …
health and disease. It is increasingly becoming apparent that cells migrating in three …
Actin-based cell protrusion in a 3D matrix
PT Caswell, T Zech - Trends in cell biology, 2018 - cell.com
Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …