Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Advanced glycation end products (AGEs) are naturally occurring biomolecules formed by
interaction of reducing sugars with biomolecules such as protein and lipids etc., Long term …

Diabetes is a leading cause of cardiovascular morbidity and mortality. Despite numerous
treatments for cardiovascular disease (CVD), for patients with diabetes, these therapies …

The elderly population in the United States is projected to almost double by the year 2050. In
addition, the numbers of diabetics are rising, along with its most common complication …

The receptor for advanced glycation end-products (RAGE) was initially characterized and
named for its ability to bind to advanced glycation end-products (AGEs) that form upon the …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

Insulin resistance is a characteristic feature of obesity and type 2 diabetes mellitus and
impacts the heart in various ways. Impaired insulin-mediated glucose uptake is a uniformly …

The process of advanced glycation leads to the generation and accumulation of an
heterogeneous class of molecules called advanced glycation endproducts, or AGEs. AGEs …

Non-enzymatic reaction involving carbonyl of reducing sugars and amino groups in proteins
produces advanced glycation end products (AGEs). AGE accumulation in vivo is a crucial …

The discovery of the receptor for advanced glycation end-products (RAGE) set the stage for
the elucidation of important mechanisms underpinning diabetic complications. RAGE …