Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

Summary Mitofusin 2 (MFN2) plays critical roles in both mitochondrial fusion and the
establishment of mitochondria-endoplasmic reticulum (ER) interactions. Hypothalamic ER …

Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin is the most critical hormone in the homeostatic regulation of energy balance among
those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of …

Background: Consumption of dietary fat is one of the key factors leading to obesity. High-fat
diet (HFD)-induced obesity is characterized by induction of inflammation in the …