The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …

Decreased heat shock protein (Hsp) expression in type 1 and type 2 diabetes has been
implicated as a primary factor contributing to diabetes-induced organ damage. We recently …

Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a
reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility …

Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …

Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic
reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human …

Depressed sarcoplasmic reticulum (SR) calcium cycling, reflecting impaired SR Ca-transport
and Ca-release, is a key and universal characteristic of human and experimental heart …