Circulating tumor DNA in B-cell lymphoma: technical advances, clinical applications, and perspectives for translational research

EM Lauer, J Mutter, F Scherer - Leukemia, 2022 - nature.com
Noninvasive disease monitoring and risk stratification by circulating tumor DNA (ctDNA)
profiling has become a potential novel strategy for patient management in B-cell lymphoma …

Genomic profiling for clinical decision making in lymphoid neoplasms

L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

[HTML][HTML] Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas

BJ Sworder, DM Kurtz, SK Alig, MJ Frank, N Shukla… - Cancer Cell, 2023 - cell.com
Most relapsed/refractory large B cell lymphoma (r/rLBCL) patients receiving anti-CD19
chimeric antigen receptor (CAR19) T cells relapse. To characterize determinants of …

Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling

SK Alig, M Shahrokh Esfahani, A Garofalo, MY Li… - Nature, 2024 - nature.com
The scarcity of malignant Hodgkin and Reed–Sternberg cells hampers tissue-based
comprehensive genomic profiling of classic Hodgkin lymphoma (cHL). By contrast, liquid …

Circulating tumor DNA profiling for detection, risk stratification, and classification of brain lymphomas

JA Mutter, SK Alig, MS Esfahani, EM Lauer… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Clinical outcomes of patients with CNS lymphomas (CNSLs) are remarkably
heterogeneous, yet identification of patients at high risk for treatment failure is challenging …

Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma

L Meriranta, A Alkodsi, A Pasanen… - Blood, The Journal …, 2022 - ashpublications.org
Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-
cell lymphoma (DLBCL) is a clinical challenge hampering the establishment of personalized …

Clinical applications of circulating tumor DNA in central nervous system lymphoma

AK Foerster, EM Lauer, F Scherer - Seminars in Hematology, 2023 - Elsevier
Detection and characterization of circulating tumor DNA (ctDNA) in body fluids has the
potential to revolutionize management of patients with lymphoma. Minimal access to …

Concurrent pembrolizumab with AVD for untreated classic Hodgkin lymphoma

RC Lynch, CS Ujjani, C Poh, EH Warren… - Blood, The Journal …, 2023 - ashpublications.org
Concurrent administration of pembrolizumab with chemotherapy in untreated classic
Hodgkin lymphoma (CHL) has not been studied previously. To investigate this combination …

Sequencing therapy in relapsed DLBCL

CR Flowers, OO Odejide - Hematology, 2022 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy
worldwide, comprising approximately 30% of all lymphomas. Currently, 50% to 60% of …

Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

JM Heger, J Mattlener, J Schneider, P Gödel, N Sieg… - Blood, 2024 - ashpublications.org
State-of-the-art response assessment of central nervous system lymphoma (CNSL) by
magnetic resonance imaging is challenging and an insufficient predictor of treatment …