Myelination of the nervous system: mechanisms and functions
Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …
propagation, one of the best-understood concepts in neurophysiology. However, it took a …
[HTML][HTML] Glia: victims or villains of the aging brain?
Aging is the strongest risk factor for metabolic, vascular and neurodegenerative diseases.
Aging alone is associated with a gradual decline of cognitive and motor functions …
Aging alone is associated with a gradual decline of cognitive and motor functions …
[HTML][HTML] The CNS myelin proteome: deep profile and persistence after post-mortem delay
Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …
has long been considered to be low. However, numerous additional myelin proteins have …
Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination
The efficiency of central nervous system remyelination declines with age. This is in part due
to an age-associated decline in the phagocytic removal of myelin debris, which contains …
to an age-associated decline in the phagocytic removal of myelin debris, which contains …
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …
[HTML][HTML] Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease
Abstract Background Oligodendrocytes (OLs) and myelin are critical for normal brain
function and have been implicated in neurodegeneration. Several lines of evidence …
function and have been implicated in neurodegeneration. Several lines of evidence …
[HTML][HTML] EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia
The exosome is a multi-protein complex, required for the degradation of AU-rich element
(ARE) containing messenger RNAs (mRNAs). EXOSC8 is an essential protein of the …
(ARE) containing messenger RNAs (mRNAs). EXOSC8 is an essential protein of the …
Golgi outposts nucleate microtubules in cells with specialized shapes
Classically, animal cells nucleate or form new microtubules off the perinuclear centrosome.
In recent years, the Golgi outpost has emerged as a satellite organelle that can function as …
In recent years, the Golgi outpost has emerged as a satellite organelle that can function as …
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction
Myelination of axons facilitates rapid impulse propagation in the nervous system. The
axon/myelin-unit becomes impaired in myelin-related disorders and upon normal aging …
axon/myelin-unit becomes impaired in myelin-related disorders and upon normal aging …
Adapting brain metabolism to myelination and long‐range signal transduction
J Hirrlinger, KA Nave - Glia, 2014 - Wiley Online Library
In the mammalian brain, the subcortical white matter comprises long‐range axonal
projections and their associated glial cells. Here, astrocytes and oligodendrocytes serve …
projections and their associated glial cells. Here, astrocytes and oligodendrocytes serve …