Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …

Polysaccharides are abundant natural polymers, which in nature are at times covalently
modified with peptides and proteins. Polysaccharide–protein or polysaccharide–peptide …

The intention of this publication is to give an overview on research related to conjugates of
polysaccharides and peptides. Dextran, chitosan, and alginate were selected, to cover four …

Site-specific conjugation of polysaccharides with proteins is very challenging. Creating the
ability to control chemo-and regioselective reaction between polysaccharides and amino …

Covalent conjugation of hyaluronidase with copolymeric glycosaminoglycans (GAG, heparin
and dermatan sulfate) considerably inactivates the enzyme, while conjugation with …

Методы вычислительной биохимии (молекулярный докинг и молекулярная динамика)
предстали современным и своевременным подходом для теоретического изучения …

Dextran nanoparticles are grabbing world-wide attention of scientists and technologists for
their wide-ranging applications as biomaterials. Dextran, a type of α-glucan is the first …

Attachment of polysaccharide carriers is increasingly being used to achieve precision
delivery and improved effectiveness of protein and peptide drugs. Although it is clear that …

Concerns towards impact on the ecosystem and the requisite to substitute toxic synthetic
polymers with the eco‐friendly ones, have increased the demand and development of …

抗菌肽是一类有望可以替代传统抗生素的生物大分子, 其来源广泛, 抗菌性能优异且不容易引起
细菌耐药性, 但抗菌肽具有容易被降解, 抗菌性能不稳定等缺陷, 在实际应用中需要通过与大分子 …