From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery
KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …
Snake bite
DA Warrell - The lancet, 2010 - thelancet.com
Snake bite is a common and frequently devastating environmental and occupational
disease, especially in rural areas of tropical developing countries. Its public health …
disease, especially in rural areas of tropical developing countries. Its public health …
Multifunctional cationic host defence peptides and their clinical applications
ATY Yeung, SL Gellatly, REW Hancock - Cellular and Molecular Life …, 2011 - Springer
With the rapid rise in the emergence of bacterial strains resistant to multiple classes of
antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to …
antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to …
Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications
LR Potter, AR Yoder, DR Flora, LK Antos… - … generators, effectors and …, 2009 - Springer
Natriuretic peptides are a family of three structurally related hormone/paracrine factors. Atrial
natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted from the cardiac …
natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted from the cardiac …
Natriuretic peptide metabolism, clearance and degradation
LR Potter - The FEBS journal, 2011 - Wiley Online Library
Atrial natriuretic peptide, B‐type natriuretic peptide and C‐type natriuretic peptide constitute
a family of three structurally related, but genetically distinct, signaling molecules that …
a family of three structurally related, but genetically distinct, signaling molecules that …
Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics
S Mangiafico, LC Costello-Boerrigter… - European heart …, 2013 - academic.oup.com
Hypertension and heart failure (HF) are common diseases that, despite advances in medical
therapy, continue to be associated with high morbidity and mortality. Therefore, innovative …
therapy, continue to be associated with high morbidity and mortality. Therefore, innovative …
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
Synthesis, secretion, function, metabolism and application of natriuretic peptides in heart failure
S Fu, P Ping, F Wang, L Luo - Journal of biological engineering, 2018 - Springer
As a family of hormones with pleiotropic effects, natriuretic peptide (NP) system includes
atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP …
atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP …
Natriuretic peptide pathways in heart failure: further therapeutic possibilities
SJ Sangaralingham, M Kuhn, V Cannone… - Cardiovascular …, 2022 - academic.oup.com
The discovery of the heart as an endocrine organ resulted in a remarkable recognition of the
natriuretic peptide system (NPS). Specifically, research has established the production of …
natriuretic peptide system (NPS). Specifically, research has established the production of …
Snake venom: from deadly toxins to life-saving therapeutics
Snakes are fascinating creatures and have been residents of this planet well before ancient
humans dwelled the earth. Venomous snakes have been a figure of fear, and cause notable …
humans dwelled the earth. Venomous snakes have been a figure of fear, and cause notable …