Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …

Cognition arises as a result of coordinated processing among distributed brain regions and
disruptions to communication within these neural networks can result in cognitive …

White matter disruption is an important determinant of cognitive impairment after brain injury,
but conventional neuroimaging underestimates its extent. In contrast, diffusion tensor …

Deterioration of the hippocampus occurs in elderly individuals with and without dementia,
yet individual variation exists in the degree and rate of hippocampal decay. Determining the …

In this article we review recent research on diffusion tensor imaging (DTI) of white matter
(WM) integrity and the implications for age-related differences in cognition. Neurobiological …

There is marked variability in both onset and rate of episodic-memory decline in aging.
Structural magnetic resonance imaging studies have revealed that the extent of age-related …

In this article, marking the 65th anniversary of the Journal of Gerontology, we offer a broad-
brush overview of the new synthesis between neuroscientific and psychological approaches …

During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …

Background Cerebral aging is a complex and heterogeneous process that is associated with
a high degree of inter‐individual variability. Structural magnetic resonance imaging (MRI) …

Background: High blood pressure has been associated with an increased risk of developing
cognitive impairment. However, this relationship is unclear. This study aims to systematically …