Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes
The effect of dietary fats on cardiometabolic diseases, including cardiovascular diseases
and type 2 diabetes mellitus, has generated tremendous interest. Many earlier investigations …
and type 2 diabetes mellitus, has generated tremendous interest. Many earlier investigations …
Palmitic acid is an intracellular signaling molecule involved in disease development
S Fatima, X Hu, RH Gong, C Huang, M Chen… - Cellular and Molecular …, 2019 - Springer
Emerging evidence shows that palmitic acid (PA), a common fatty acid in the human diet,
serves as a signaling molecule regulating the progression and development of many …
serves as a signaling molecule regulating the progression and development of many …
[HTML][HTML] Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical …
G Togliatto, P Dentelli, M Gili, S Gallo… - International journal of …, 2016 - nature.com
Methods: ASCs were recovered from 10 obese (oASCs) and 6 non-obese (nASCs)
participants and characterized. In selected experiments, nASCs and oASCs were cultured …
participants and characterized. In selected experiments, nASCs and oASCs were cultured …
Modulating putative endothelial progenitor cells for the treatment of endothelial dysfunction and cardiovascular complications in diabetes
J Wils, J Favre, J Bellien - Pharmacology & therapeutics, 2017 - Elsevier
Diabetes induces a decrease in the number and function of different pro-angiogenic cell
types generically designated as putative endothelial progenitor cells (EPC), which …
types generically designated as putative endothelial progenitor cells (EPC), which …
[HTML][HTML] Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis
KA Parham, JR Zebol, KL Tooley, WY Sun… - The FASEB …, 2015 - ncbi.nlm.nih.gov
Abstract Sphingosine 1-phosphate (S1P) is a bioactive lipid that can function both
extracellularly and intracellularly to mediate a variety of cellular processes. Using lipid …
extracellularly and intracellularly to mediate a variety of cellular processes. Using lipid …
[HTML][HTML] Activated Stat5 trafficking via endothelial cell-derived extracellular vesicles controls IL-3 pro-angiogenic paracrine action
G Lombardo, P Dentelli, G Togliatto, A Rosso, M Gili… - Scientific reports, 2016 - nature.com
Soluble factors and cell-derived extracellular vesicles (EVs) control vascular cell fate during
inflammation. The present study investigates the impact of Interleukin 3 (IL-3) on EV release …
inflammation. The present study investigates the impact of Interleukin 3 (IL-3) on EV release …
[HTML][HTML] Adipocyte fatty acid-binding protein promotes palmitate-induced mitochondrial dysfunction and apoptosis in macrophages
H Li, Y Xiao, L Tang, F Zhong, G Huang, JM Xu… - Frontiers in …, 2018 - frontiersin.org
A high level of circulating free fatty acids (FFAs) is known to be an important trigger for
macrophage apoptosis during the development of atherosclerosis. However, the underlying …
macrophage apoptosis during the development of atherosclerosis. However, the underlying …
[HTML][HTML] IFN-γ and TNF-α pre-licensing protects mesenchymal stromal cells from the pro-inflammatory effects of palmitate
The use of mesenchymal stromal cell (MSC) therapy for the treatment of type 2 diabetes
(T2D) and T2D complications is promising; however, the investigation of MSC function in the …
(T2D) and T2D complications is promising; however, the investigation of MSC function in the …
[HTML][HTML] Endothelial progenitor cell derived exosomes mediated miR-182-5p delivery accelerate diabetic wound healing via down-regulating PPARG
P Li, G Hong, W Zhan, M Deng, C Tu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Diabetic wound is one of the most common and serious complications of diabetes, which is
characterized by abnormal number and quality of wound repair related cells. Previous …
characterized by abnormal number and quality of wound repair related cells. Previous …
[HTML][HTML] Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation
S Bo, G Togliatto, R Gambino, V Ponzo, G Lombardo… - Acta …, 2018 - Springer
Abstract Aims Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has
been associated with epigenetic markers of oxidative stress. We herein aim to evaluate …
been associated with epigenetic markers of oxidative stress. We herein aim to evaluate …