The best intervention to prevent pain on injection with propofol is unknown. We conducted a
systematic literature search (Medline, Embase, Cochrane Library, bibliographies, hand …

Pain on injection of propofol is a common problem, the cause of which remains unknown.
The chemical properties and preparation of propofol, proposed mechanisms for the cause of …

Objective: Ciprofol is a new intravenous anesthetic agent similar to propofol that has the
pharmacodynamic characteristics of a rapid rate of onset and recovery in pre-clinical …

Synopsis Propofol is an intravenous sedative hypnotic agent which rapidly and reliably
causes loss of consciousness. It is also associated with a quick and 'smooth'recovery, which …

Although questions may still remain regarding the use of this unique sedative-hypnotic drug
with anesthetic properties in highrisk patients, these studies have provided cardiopulmonary …

Background Ciprofol is a recently developed, short-acting γ-aminobutyric acid receptor
agonist sedative that is more potent than propofol, but there have been few clinical studies of …

We undertook a randomized, placebo-controlled, double-blind study to compare the use of
alfentanil 1 mg and lidocaine 40 mg for the reduction of pain during injection of propofol …

Background Propofol-induced injection pain (PIP) is a well-known problem in general
anesthesia. We hypothesized that pre-treatment with remimazolam prevents PIP in patients …

Background and Objectives. Tramadol and metoclopramide have a local anesthetic effect
similar to lidocaine following intradermal injection. When metoclopramide was retained in …

Propofol has the disadvantage of pain on injection. A higher partition of propofol in the
aqueous phase of the preparation causes a higher incidence of pain on injection while …