The ability of chitosan (CTS) to promote mucoadhesion, trigger positive/negative surface
interactions, and open tight junctions has inspired researchers to coat lipid-based and …

Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after
cellulose, is the second biopolymer most abundant in nature, being the primary component …

Traditionally, herbal compounds have been the focus of scientific interest for the last several
centuries, and continuous research into their medicinal potential is underway. Berberine …

Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis
chinensis and other Berberis plants. BBR possesses various bioactivities, including …

Rheumatoid arthritis (RA) is a chronic inflammatory illness affecting the joints. The
characteristic of RA is gradual joint deterioration. Current RA treatment alleviates signs such …

Sufficient ocular bioavailability is often considered a challenge by the researchers, due to
the complex structure of the eye and its protective physiological mechanisms. In addition, the …

The research was aimed to formulate the Donepezil (DPZ)-loaded nanostructured lipid
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …

The objective of the present research was to develop, optimize, and evaluate rotigotine (RT)-
loaded chitosan (CH) coated nanostructured lipid carriers (RT-CH-NLCs) for nose-to-brain …

Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain
barrier and systemic adverse effects. Intranasal administration offers a direct route to the …

This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to
better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 …