Extensive studies of the genetic aberrations related to human diseases conducted over the
last two decades have identified recurrent genomic abnormalities as potential driving factors …

Fluorescence in situ hybridization (FISH) is a macromolecule recognition technique, which is
considered as a new advent in the field of cytology. Initially, it was developed as a physical …

Multiple studies have demonstrated the utility of chromosomal microarray (CMA) testing to
identify clinically significant copy number alterations (CNAs) and copy-neutral loss-of …

The myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders of
ineffective hematopoiesis that characteristically demonstrate peripheral blood cytopenia …

Cytogenetic aberrations identified by metaphase cytogenetics (MC) have diagnostic,
prognostic, and therapeutic implications in myelodysplastic syndromes (MDS). However, in …

The clinical course of patients with myelodysplastic syndromes (MDS) is characterized by
wide variability reflecting the underlying genetic and biological heterogeneity of the disease …

Aberrant methylation of CCAAT/enhancer-binding protein alpha (CEBPA) promoter has
been observed in acute myeloid leukemia. However, little is known about CEBPA promoter …

Objectives: The current standard of practice for evaluation of myelodysplastic syndromes
(MDS) includes peripheral blood and bone marrow morphology review and conventional …

The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is
conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most …

Abstract International Prognostic Scoring Systems are used to determine the individual risk
profile of myelodysplastic syndrome patients. For the assessment of International Prognostic …