Connexins and pannexins are two families of large-pore channel forming proteins that are
capable of passing small signaling molecules. While connexins serve the seminal task of …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Background In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed
in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression …

Parkinson's disease (PD) is a neurological disorder that affects the movement of the human
body. It is primarily characterized by reduced dopamine levels in the brain. The causative …

Microglia represent the immune system of the brain. Their role is central in two phenomena,
neuroinflammation and oxidative stress, which are at the roots of different pathologies …

Autosomal dominant sleep‐related hypermotor epilepsy (ADSHE; previously autosomal
dominant nocturnal frontal lobe epilepsy, ADNFLE), originally reported in 1994, was the first …

Astrocytes have emerged as major players in the brain, contributing to many functions such
as energy supply, neurotransmission, and behavior. They accomplish these functions in part …

Mood disorders remain a major public health concern worldwide. Monoaminergic
hypotheses of pathophysiology of bipolar and major depressive disorders have led to the …

Depression is a common mood disorder characterized by a range of clinical symptoms,
including prolonged low mood and diminished interest. Although many clinical and animal …

Recently, accumulating preclinical findings suggest the possibility that functional
abnormalities of tripartite synaptic transmission play important roles in the pathophysiology …