Airflow and particle transport in the human respiratory system

C Kleinstreuer, Z Zhang - Annual review of fluid mechanics, 2010 - annualreviews.org
Airflows in the nasal cavities and oral airways are rather complex, possibly featuring a
transition to turbulent jet-like flow, recirculating flow, Dean's flow, vortical flows, large …

Deposition of inhaled particles in the lungs

AF Tena, PC Clarà - Archivos de Bronconeumología (English Edition), 2012 - Elsevier
Inhaled medication is the first-line treatment of diseases such as asthma or chronic
obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited …

[图书][B] Multiphase flow handbook

E Michaelides, CT Crowe, JD Schwarzkopf - 2016 - books.google.com
The Multiphase Flow Handbook, Second Edition is a thoroughly updated and reorganized
revision of the late Clayton Crowe's work, and provides a detailed look at the basic concepts …

A review of respiratory anatomical development, air flow characterization and particle deposition

MS Islam, G Paul, HX Ong, PM Young, YT Gu… - International journal of …, 2020 - mdpi.com
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

[HTML][HTML] Computational modeling and validation of human nasal airflow under various breathing conditions

C Li, J Jiang, H Dong, K Zhao - Journal of biomechanics, 2017 - Elsevier
The human nose serves vital physiological functions, including warming, filtration,
humidification, and olfaction. These functions are based on transport phenomena that …

[HTML][HTML] Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery–a review for multidisciplinary researchers

N Islam, MJ Cleary - Medical engineering & physics, 2012 - Elsevier
Pulmonary drug delivery is the focus of much research and development because of its
great potential to produce maximum therapeutic benefit. Among the available options the dry …

Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract

F Huang, Q Zhu, X Zhou, D Gou, J Yu, R Li… - Advanced drug delivery …, 2021 - Elsevier
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …

An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition

Y Feng, J Zhao, C Kleinstreuer, Q Wang, J Wang… - Journal of Aerosol …, 2018 - Elsevier
An understanding of human inter-subject variability is crucial for the implementation of
personalized pulmonary drug delivery as well as exposure assessment of airborne …

Aging effects on airflow distribution and micron-particle transport and deposition in a human lung using CFD-DPM approach

MM Rahman, M Zhao, MS Islam, K Dong… - Advanced Powder …, 2021 - Elsevier
Understanding the transportation and deposition (TD) of inhaled aerosol particles in human
lung airways is important for health risk assessment and therapeutic efficiency of targeted …

Laminar‐to‐turbulent fluid–nanoparticle dynamics simulations: Model comparisons and nanoparticle‐deposition applications

Z Zhang, C Kleinstreuer - International Journal for Numerical …, 2011 - Wiley Online Library
Relying on benchmark experimental data sets for flow in conduits with local constrictions,
LES and three widely used RANS turbulence models, ie the low Reynolds number (LRN) k …