Hfq and its constellation of RNA
J Vogel, BF Luisi - Nature Reviews Microbiology, 2011 - nature.com
Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key
roles in the control of gene expression. By facilitating the pairing of small RNAs with their …
roles in the control of gene expression. By facilitating the pairing of small RNAs with their …
RNase E: at the interface of bacterial RNA processing and decay
GA Mackie - Nature Reviews Microbiology, 2013 - nature.com
RNase E is an essential endonuclease that is abundant in many bacteria and plays an
important part in all aspects of RNA metabolism. It functions as part of a large …
important part in all aspects of RNA metabolism. It functions as part of a large …
[HTML][HTML] In vivo cleavage map illuminates the central role of RNase E in coding and non-coding RNA pathways
Understanding RNA processing and turnover requires knowledge of cleavages by major
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …
The critical role of RNA processing and degradation in the control of gene expression
CM Arraiano, JM Andrade, S Domingues… - FEMS microbiology …, 2010 - academic.oup.com
The continuous degradation and synthesis of prokaryotic mRNAs not only give rise to the
metabolic changes that are required as cells grow and divide but also rapid adaptation to …
metabolic changes that are required as cells grow and divide but also rapid adaptation to …
Structure of Escherichia coli Hfq bound to polyriboadenylate RNA
TM Link, P Valentin-Hansen… - Proceedings of the …, 2009 - National Acad Sciences
Hfq is a small, highly abundant hexameric protein that is found in many bacteria and plays a
critical role in mRNA expression and RNA stability. As an “RNA chaperone,” Hfq binds AU …
critical role in mRNA expression and RNA stability. As an “RNA chaperone,” Hfq binds AU …
Small RNA interactome of pathogenic E. coli revealed through crosslinking of RNase E
RNA sequencing studies have identified hundreds of non‐coding RNA s in bacteria,
including regulatory small RNA (sRNA). However, our understanding of sRNA function has …
including regulatory small RNA (sRNA). However, our understanding of sRNA function has …
Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation
V Pfeiffer, K Papenfort, S Lucchini… - Nature structural & …, 2009 - nature.com
Bacterial small noncoding RNAs (sRNAs) generally recognize target mRNAs in the 5′
region to prevent 30S ribosomes from initiating translation. It was thought that the mRNA …
region to prevent 30S ribosomes from initiating translation. It was thought that the mRNA …
[HTML][HTML] The seed region of a small RNA drives the controlled destruction of the target mRNA by the endoribonuclease RNase E
Numerous small non-coding RNAs (sRNAs) in bacteria modulate rates of translation
initiation and degradation of target mRNAs, which they recognize through base-pairing …
initiation and degradation of target mRNAs, which they recognize through base-pairing …
[HTML][HTML] Bacterial small RNA-based negative regulation: Hfq and its accomplices
N De Lay, DJ Schu, S Gottesman - Journal of Biological Chemistry, 2013 - ASBMB
A large group of bacterial small regulatory RNAs (sRNAs) use the Hfq chaperone to mediate
pairing with and regulation of mRNAs. Recent findings help to clarify how Hfq acts and …
pairing with and regulation of mRNAs. Recent findings help to clarify how Hfq acts and …
Structural basis for RNA 3′-end recognition by Hfq
E Sauer, O Weichenrieder - Proceedings of the National …, 2011 - National Acad Sciences
The homohexameric (L) Sm protein Hfq is a central mediator of small RNA-based gene
regulation in bacteria. Hfq recognizes small regulatory RNAs (sRNAs) specifically, despite …
regulation in bacteria. Hfq recognizes small regulatory RNAs (sRNAs) specifically, despite …