Amyloid formation as a protein phase transition
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …
is associated with both functional biology and the development of a number of disorders …
A new phase of networking: the molecular composition and regulatory dynamics of mammalian stress granules
SR Millar, JQ Huang, KJ Schreiber, YC Tsai… - Chemical …, 2023 - ACS Publications
Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …
A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53
Long noncoding RNAs (lncRNA) have been associated with various types of cancer;
however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we …
however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we …
[HTML][HTML] G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits
Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are
assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now …
assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now …
Spatiotemporal proteomic analysis of stress granule disassembly using APEX reveals regulation by SUMOylation and links to ALS pathogenesis
H Marmor-Kollet, A Siany, N Kedersha, N Knafo… - Molecular cell, 2020 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs.
Whereas much has been learned about SG formation, a major gap remains in …
Whereas much has been learned about SG formation, a major gap remains in …
The integral role of RNA in stress granule formation and function
D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …
(RNP) assemblies whose primary function is to promote cell survival by condensing …
[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease
H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …
damage and promote cell survival. Beyond their fundamental role in the stress response …
[HTML][HTML] SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …
essential for viral replication, making it a promising target for antiviral drug and vaccine …
RNA–protein interaction mapping via MS2-or Cas13-based APEX targeting
RNA–protein interactions underlie a wide range of cellular processes. Improved methods
are needed to systematically map RNA–protein interactions in living cells in an unbiased …
are needed to systematically map RNA–protein interactions in living cells in an unbiased …
Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?
A Aulas, C Vande Velde - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Stress granules (SGs) are RNA-containing cytoplasmic foci formed in response to stress
exposure. Since their discovery in 1999, over 120 proteins have been described to be …
exposure. Since their discovery in 1999, over 120 proteins have been described to be …