Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

Numerous drugs and endogenous ligands bind to cell surface receptors leading to
modulation of downstream signaling cascades and frequently to adaptation of the plasma …

Protein localisation and translocation between intracellular compartments underlie almost
all physiological processes. The hyperLOPIT proteomics platform combines mass …

Chemical probes represent versatile tools to validate disease-modifying targets. However,
evaluating the selectivity of chemical probes in complex cellular systems is a major …

In recent years, phenotypic-based screens have become increasingly popular in drug
discovery. A major challenge of this approach is that it does not provide information about …

Prostate cancer (PCa) is the second most prevalent malignancy in males across the world. A
greater knowledge of the relationship between protein abundance and drug responses …

Streptavidin‐mediated enrichment is a powerful strategy to identify biotinylated
biomolecules and their interaction partners; however, intense streptavidin‐derived peptides …

Introduction: Cancer is the second most common cause of death worldwide and its
heterogeneity complicates therapy. Standard cytotoxic regiments disrupt rapidly dividing …

Cardiac cell surface proteins are drug targets and useful biomarkers for discriminating
among cellular phenotypes and disease states. Here we developed an analytical platform …