Islet inflammation in type 2 diabetes and physiology
K Eguchi, R Nagai - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …
dysfunction has further highlighted the significance of inflammation in metabolic diseases …
Signals in the pancreatic islet microenvironment influence β‐cell proliferation
KI Aamodt, AC Powers - Diabetes, Obesity and Metabolism, 2017 - Wiley Online Library
The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …
[HTML][HTML] Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration
M Brissova, K Aamodt, P Brahmachary, N Prasad… - Cell metabolism, 2014 - cell.com
Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …
Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization
H Cucak, LG Grunnet… - Journal of leukocyte …, 2014 - academic.oup.com
Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and
diminished insulin production. Local islet immunity is still poorly understood, and hence, we …
diminished insulin production. Local islet immunity is still poorly understood, and hence, we …
The islet endothelial cell: a novel contributor to beta cell secretory dysfunction in diabetes
MF Hogan, RL Hull - Diabetologia, 2017 - Springer
The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …
Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect
Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …
microenvironments that are rich in cellular and acellular components. Intricate interactions …
Engineering the vasculature for islet transplantation
The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …
Engineered VEGF-releasing PEG–MAL hydrogel for pancreatic islet vascularization
EA Phelps, KL Templeman, PM Thulé… - Drug delivery and …, 2015 - Springer
Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …
New insights into the architecture of the islet of Langerhans: a focused cross-species assessment
The human genome project and its search for factors underlying human diseases has
fostered a major human research effort. Therefore, unsurprisingly, in recent years we have …
fostered a major human research effort. Therefore, unsurprisingly, in recent years we have …
Physiological changes and pathological pain associated with sedentary lifestyle-induced body systems fat accumulation and their modulation by physical exercise
E Verdú, J Homs, P Boadas-Vaello - International journal of …, 2021 - mdpi.com
A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …
body accumulation, triggering structural and functional changes in tissues, organs, and body …