Breakthroughs in hepatitis C research: from discovery to cure

MP Manns, B Maasoumy - Nature reviews Gastroenterology & …, 2022 - nature.com
In the 1970s, an unknown virus was suspected for documented cases of transfusion-
associated hepatitis, a phenomenon called non-A, non-B hepatitis. In 1989, the infectious …

Hepatitis C virus infection

MP Manns, M Buti, ED Gane, JM Pawlotsky… - Nature reviews Disease …, 2017 - nature.com
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …

[HTML][HTML] Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents

JE Kaplan, C Benson, KK Holmes, JT Brooks, A Pau… - MMWR Recomm …, 2009 - cdc.gov
This report updates and combines earlier versions of guidelines for the prevention and
treatment of opportunistic infections (OIs) in HIV-infected adults (ie, persons aged> 18 years) …

[PDF][PDF] Diagnosis, management, and treatment of hepatitis C: an update

MG Ghany, DB Strader, DL Thomas, LB Seeff - Hepatology, 2009 - Wiley Online Library
Background The hepatitis C virus (HCV) is a major public health problem and a leading
cause of chronic liver disease. 5 An estimated 180 million people are infected worldwide. 6 …

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

M Omata, LA Lesmana, R Tateishi, PJ Chen… - Hepatology …, 2010 - Springer
Abstract Introduction The Asian Pacific Association for the Study of the Liver (APASL)
convened an international working party on the management of hepatocellular carcinoma …

Global epidemiology of hepatitis C virus infection

CW Shepard, L Finelli, MJ Alter - The Lancet infectious diseases, 2005 - thelancet.com
Hepatitis C virus (HCV) is a major cause of liver disease worldwide and a potential cause of
substantial morbidity and mortality in the future. The complexity and uncertainty related to …

[PDF][PDF] Diagnosis, management, and treatment of hepatitis C

DB Strader, T Wright, DL Thomas, LB Seeff - Hepatology, 2004 - Wiley Online Library
Background The hepatitis C virus (HCV) is a major public health problem and a leading
cause of chronic liver disease. In the United States, the Centers for Disease Control and …

Mechanism of action of interferon and ribavirin in treatment of hepatitis C

JJ Feld, JH Hoofnagle - Nature, 2005 - nature.com
Since the identification of the hepatitis C virus, great strides have been made in the
development of an antiviral therapy. As a crucial mediator of the innate antiviral immune …

Biologics for targeting inflammatory cytokines, clinical uses, and limitations

P Rider, Y Carmi, I Cohen - International journal of cell biology, 2016 - Wiley Online Library
Proinflammatory cytokines are potent mediators of numerous biological processes and are
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …

Viral hepatitis C

T Poynard, MF Yuen, V Ratzin, CL Lai - The Lancet, 2003 - thelancet.com
Epidemiology Chronic hepatitis C virus infection is a major cause of chronic liver disease
and death throughout the world. 1, 2, 4–9 Very effective treatment is now available, which …