Coiled‐coils: The long and short of it
L Truebestein, TA Leonard - Bioessays, 2016 - Wiley Online Library
Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …
of some proteins are almost invariant in sequence and length, betraying a structural and …
Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling
M Takeichi - Nature reviews Molecular cell biology, 2014 - nature.com
Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …
changes, particularly during embryonic development and in equivalent processes in adults …
Accurate de novo prediction of protein contact map by ultra-deep learning model
Motivation Protein contacts contain key information for the understanding of protein structure
and function and thus, contact prediction from sequence is an important problem. Recently …
and function and thus, contact prediction from sequence is an important problem. Recently …
Rho‐associated kinases in tumorigenesis: re‐considering ROCK inhibition for cancer therapy
N Rath, MF Olson - EMBO reports, 2012 - embopress.org
The Rho‐associated (ROCK) serine/threonine kinases have emerged as central regulators
of the actomyosin cytoskeleton, their main purpose being to promote contractile force …
of the actomyosin cytoskeleton, their main purpose being to promote contractile force …
A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of
complex tissues during development. Important roles for actomyosin during tissue …
complex tissues during development. Important roles for actomyosin during tissue …
[HTML][HTML] β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis
Rosettes are widely used in epithelial morphogenesis during embryonic development and
organogenesis. However, their role in postnatal development and adult tissue maintenance …
organogenesis. However, their role in postnatal development and adult tissue maintenance …
Apical sarcomere-like actomyosin contracts nonmuscle Drosophila epithelial cells
JS Coravos, AC Martin - Developmental cell, 2016 - cell.com
Actomyosin networks generate contractile force that changes cell and tissue shape. In
muscle cells, actin filaments and myosin II appear in a polarized structure called a …
muscle cells, actin filaments and myosin II appear in a polarized structure called a …
Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure
Neural tube closure is a critical developmental event that relies on actomyosin contractility to
facilitate specific processes such as apical constriction, tissue bending, and directional cell …
facilitate specific processes such as apical constriction, tissue bending, and directional cell …
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases
L Truebestein, DJ Elsner, E Fuchs… - Nature communications, 2015 - nature.com
The Rho-associated coiled-coil kinases (ROCK) are essential regulators of the actin
cytoskeleton; however, the structure of a full-length ROCK is unknown and the mechanisms …
cytoskeleton; however, the structure of a full-length ROCK is unknown and the mechanisms …
SHROOM2 inhibits tumor metastasis through RhoA–ROCK pathway-dependent and-independent mechanisms in nasopharyngeal carcinoma
SHROOM2 is a key mediator of RhoA–ROCK pathway that regulates cell motility and actin
cytoskeleton organization. However, the functions of SHROOM2 beyond RhoA/ROCK …
cytoskeleton organization. However, the functions of SHROOM2 beyond RhoA/ROCK …