The elucidation of PON1 structure and its active center has enabled a better understanding
of its mechanism of action, including its physio-pathological substrate (s). Some drugs and …

Abstract Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is
physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL …

The obesity epidemic has spawned an unlimited array of quick-fix, rapid weight loss plans
and unproven pharmaceuticals. Dangerous side effects and rebound weight gain has made …

Background Paraoxonase‐1 is an enzyme with three activities which are inversely related to
cardiovascular diseases. Accordingly, the aim of the study was to investigate the …

Preclinical studies have shown positive effects of statins against specific cancers. This study
aimed to determine the therapeutic effect of simvastatin in 12‐dimethylbenz (a) anthracene …

Objectives To study the resistance of HDL particles to direct oxidation in respect to the
distribution of HDL particles. Design and Methods We studied HDL composition, subclass …

Hypercholesterolemia is characterized with changes in lipid profile, nitric oxide pathway and
oxidative stress markers. This study is designed to evaluate the effects of …

Background This represents the first update of this review, which was published in 2012.
Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin …

It has been proposed that paraoxonase1 (PON1), a high density lipoprotein (HDL)-
associated esterase/lactonase, has anti-atherosclerotic properties. The activity of PON1 is …

Background: While cases of amyotrophic lateral sclerosis (ALS) or ALS-like conditions have
arisen in apparent association with HMG-CoA reductase inhibitors ('statins') and/or other …