As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

Cyclic cell-penetrating peptides are relatively a newer class of peptides that have a huge
potential for the intracellular delivery of therapeutic agents aimed at treating challenging …

Doxorubicin (Dox) is used for breast cancer, leukemia, and lymphoma treatment as an
effective chemotherapeutic agent. However, Dox use is restricted due to inherent and …

A series of cyclic peptides,[(DipR)(WR) 4],[(DipR) 2 (WR) 3],[(DipR) 3 (WR) 2],[(DipR) 4
(WR)], and [DipR] 5, and their linear counterparts containing arginine (R) as positively …

Short-interfering RNA (siRNA) oligonucleotide therapeutics that modify gene expression by
accessing RNA-interference (RNAi) pathways have great promise for the treatment of a …

Recent approvals of siRNA-based products motivated the scientific community to explore
siRNA as a treatment option for several intractable ailments, especially cancer. The success …

RNAi is a biological process that utilizes small interfering RNA (siRNA) to prevent the
translation of mRNA to protein. This mechanism could be beneficial in preventing the …

Cell-impermeable and negatively charged compounds' cellular uptake across the cell
membranes remains challenging. Herein, the synthesis of four linear [(WWRR) 2,(WWRR) …

RNA interference (RNAi) is a powerful tool capable of targeting virtually any protein without
time-consuming and expensive drug development studies. However, due to obstacles facing …

Vascular endothelial growth factor (VEGF) is considered as one of the vital growth factors for
angiogenesis, which is primarily responsible for the progress and maintenance of new …