This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma
risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Stromal responses elicited by early stage neoplastic lesions can promote tumor growth.
However, the molecular mechanisms that underlie the early recruitment of stromal cells to …

Purpose: Despite recent therapeutic advances, prognosis of patients with pancreatic
adenocarcinoma remains poor. Analyses from tumor tissues present limitations; …

Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including
cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to …

Clinical evidence indicates that mutation/activation of EGF receptors (EGFRs) is mutually
exclusive with the presence of K-RAS oncogenes in lung and colon tumors. We have …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Background Histologic characteristics have proven to be very useful for classifying different
types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long …

Background & Aims There has not been a broad analysis of the combined effects of altered
activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma (PDAC) cells, and it …

Pancreatic adenocarcinoma (PAAD) is a common, highly malignant, and aggressive
gastrointestinal tumor. The conventional treatment of PAAD shows poor results, and patients …