Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Clinical trials targeting secondary damage after traumatic spinal cord injury

ZZ Khaing, JY Chen, G Safarians, S Ezubeik… - International journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a
significant reduction in quality of life for patients. Currently, no therapies are available that …

Targeting senescent cells improves functional recovery after spinal cord injury

D Paramos-de-Carvalho, I Martins, AM Cristovao… - Cell Reports, 2021 - cell.com
Persistent senescent cells (SCs) are known to underlie aging-related chronic disorders, but
it is now recognized that SCs may be at the center of tissue remodeling events, namely …

[HTML][HTML] Activating transcription factor 3 (ATF3) protects retinal ganglion cells and promotes functional preservation after optic nerve crush

C Kole, B Brommer, N Nakaya… - … & Visual Science, 2020 - tvst.arvojournals.org
Purpose: To investigate the possible role of activating transcription factor 3 (ATF3) in retinal
ganglion cell (RGC) neuroprotection and optic nerve regeneration after optic nerve crush …

Nature's electric potential: a systematic review of the role of bioelectricity in wound healing and regenerative processes in animals, humans, and plants

SEB Tyler - Frontiers in physiology, 2017 - frontiersin.org
Natural endogenous voltage gradients not only predict and correlate with growth and
development but also drive wound healing and regeneration processes. This review …

Neuronal regeneration from ependymo-radial glial cells: cook, little pot, cook!

CG Becker, T Becker - Developmental Cell, 2015 - cell.com
Adult fish and salamanders regenerate specific neurons as well as entire CNS areas after
injury. Recent studies shed light on how these anamniotes activate progenitor cells …

Delineating the roles of neutrophils and macrophages in zebrafish regeneration models

MC Keightley, CH Wang, V Pazhakh… - The international journal …, 2014 - Elsevier
The outcome following injury can be healing, scarring or regeneration, all of which initiate
within a resolving inflammatory response. Regeneration, comprising the complete …

Cell transplantation and secretome based approaches in spinal cord injury regenerative medicine

RC Assuncao Silva, L Pinto… - Medicinal Research …, 2022 - Wiley Online Library
The axonal growth‐restrictive character of traumatic spinal cord injury (SCI) makes finding a
therapeutic strategy a very demanding task, due to the postinjury events impeditive to …

The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

SD Ackerman, KR Monk - Brain research, 2016 - Elsevier
Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action
potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts …

Zebrafish as a translational regeneration model to study the activation of neural stem cells and role of their environment

M Ceci, V Mariano, N Romano - Reviews in the Neurosciences, 2018 - degruyter.com
The review is an overview of the current knowledge of neuronal regeneration properties in
mammals and fish. The ability to regenerate the damaged parts of the nervous tissue has …