Melatonin: new insights on its therapeutic properties in diabetic complications

MH Pourhanifeh, A Hosseinzadeh… - Diabetology & metabolic …, 2020 - Springer
Diabetes and diabetic complications are considered as leading causes of both morbidity
and mortality in the world. Unfortunately, routine medical treatments used for affected …

Diabetes mellitus and melatonin: Where are we?

R Patel, N Parmar, SP Palit, N Rathwa… - Biochimie, 2022 - Elsevier
Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …

Reduction of renal superoxide dismutase in progressive diabetic nephropathy

H Fujita, H Fujishima, S Chida… - Journal of the …, 2009 - journals.lww.com
Superoxide excess plays a central role in tissue damage that results from diabetes, but the
mechanisms of superoxide overproduction in diabetic nephropathy (DN) are incompletely …

Mitochondrial oxidative stress and cell death in podocytopathies

YT Zhu, C Wan, JH Lin, HP Hammes, C Zhang - Biomolecules, 2022 - mdpi.com
Podocytopathies are kidney diseases that are driven by podocyte injury with proteinuria and
proteinuria-related symptoms as the main clinical presentations. Albeit podocytopathies are …

Melatonin and renal protection: novel perspectives from animal experiments and human studies

J Hrenak, L Paulis, K Repova, S Aziriova… - Current …, 2015 - ingentaconnect.com
Chronic kidney disease (CKD) is a serious public health problem. Current therapies are
designed to slow down progression of the disease and avoid the necessity of dialysis or …

The impact of environmental contamination on the generation of reactive oxygen and nitrogen species–Consequences for plants and humans

J Drzeżdżon, D Jacewicz, L Chmurzyński - Environment international, 2018 - Elsevier
Environmental contaminants, such as heavy metals, nanomaterials, and pesticides, induce
the formation of reactive oxygen and nitrogen species (RONS). Plants interact closely with …

Therapeutic application of nutraceuticals in diabetic nephropathy: Current evidence and future implications

E Dehdashtian, MH Pourhanifeh… - Diabetes/Metabolism …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a common metabolic disease which may cause several
complications, such as diabetic nephropathy (DN). The routine medical treatments used for …

Sodium glucose co-transporter 2 inhibitor ameliorates autophagic flux impairment on renal proximal tubular cells in obesity mice

K Fukushima, S Kitamura, K Tsuji, Y Sang… - International journal of …, 2020 - mdpi.com
Obesity is supposed to cause renal injury via autophagy deficiency. Recently, sodium
glucose co-transporter 2 inhibitors (SGLT2i) were reported to protect renal injury. However …

Protective effects of allicin on streptozotocin‐induced diabetic nephropathy in rats

H Huang, Y Jiang, G Mao, F Yuan… - Journal of the …, 2017 - Wiley Online Library
BACKGROUND Studies in animal models have shown that allicin, a major biologically
active component of garlic, can play a role in the prevention of tissue fibrosis in the liver …

[HTML][HTML] Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model

ZZ Ji, YC Xu - Molecular medicine reports, 2016 - spandidos-publications.com
Diabetic nephropathy (DN) is a severe renal disorder characterized by podocyte damage
and accumulation of extracellular matrix leading to further glomerulosclerosis, possibly via …